Glutamine Synthetase: Localization Dictates Outcome
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منابع مشابه
Glutamine Synthetase: Localization Dictates Outcome
Glutamine synthetase (GS) is the adenosine triphosphate (ATP)-dependent enzyme that catalyses the synthesis of glutamine by condensing ammonium to glutamate. In the circulatory system, glutamine carries ammonia from muscle and brain to the kidney and liver. In brain reduction of GS activity has been suggested as a mechanism mediating neurotoxicity in neurodegenerative disorders. In cancer, the ...
متن کاملLocalization and function of glutamine synthetase and glutaminase.
Storm-Mathisen, J. (1977) Brain Res. 120, 379-386 Storm-Mathisen, J. & Iversen, L. L. (1979) Neuroscience 4, 1237-1253 Storm-Mathisen, J. & Ottersen, 0. P. (1986) in Neurohisfochemistry: Modern Merhods and Applications (Panula, P., Paivarinta, H. & Soinila, S., eds.), pp. 107-136, Alan R. Liss, New York Storm-Mathisen, J. & Ottersen, 0. P. (1987) in Neurorransmiffers and Brain Function (Avoli, ...
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We report here for the first time, in chick retina, Muller cell localization of glutamine synthetase (GS) activity by an immunohistochemical technique, in agreement with previous reports of glial localization of this enzyme in rat brain and retina. Age-dependent changes in the endogenous enzyme activity as well as cortisol-induced changes in GS activity, both in ovo and in vitro, measured bioch...
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We have examined three mutants of Klebsiella aerogenes whose genetic lesions (glnB, glnD, and glnE) are in loci unlinked to the structural gene for glutamine sythetase (glnA) and in which the control of both the level and state of adenylylation of glutamine synthetase is altered. Each mutation alters a different component of the adenylylation system of glutamine synthetase [L-glutamate:ammonia ...
متن کاملChinese Hamster Liver Glutamine Synthetase
Purification procedures to prepare homogeneous glutamine synthetase from Chinese hamster liver and a sensitive radioisotope assay for the enzyme are described. The enzyme has a molecular weight of 335,000 as determined by sedimentation in a glycerol gradient, and consists of 8 identical subunits with molecular weights of 42,000 as determined by mobility in sodium dodecyl sulfate polyacrylamide ...
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ژورنال
عنوان ژورنال: Genes
سال: 2018
ISSN: 2073-4425
DOI: 10.3390/genes9020108